This depends which of Salad's miners you are running on your machine.
For CPU mining, we do not recommend using your PC at the same time as running Salad. This is because your CPU is being utilised by Salad to 100%, and this leaves no room for running other applications. We in fact advise closing any and all background applications to maximise your profits if using this option to earn.
For GPU mining, Salad will fully utilize your Graphics Card (GPU) while running. This means that applications which rely on your GPU may not be able to run smoothly, if at all. This includes gaming, media applications, and (of course) GPU cryptomining. However, some programs do not need your GPU to function, like Google Chrome and Microsoft Word. These applications should run fine while Salad chops away in the background.